The long-term clinical course of moderate tricuspid regurgitation

Abstract Background Moderate TR is a frequent condition, worsening mid and long-term survival, particularly in patients >75 years old, those suffering from left ventricular systolic dysfunction. As often clinically unsuspected until an advanced stage of congestive heart failure (HF), there great need early diagnosis appropriate follow-up. However, data focusing on the clinical echocardiographic course cohort with moderate lacking, most type time management these still heavily debated. Purpose To evaluate evolution outcome to severe TR, regardless its etiology. Methods Clinical follow-up were assessed 212 diagnosed our centre between January 2014 December 2019. progression at was defined as grade increase least severe. The primary endpoint all-cause death; secondary endpoints cardiovascular (CV) death HF hospitalization. Results After median 4.2 years, occurred 76 (36%): presented more history coronary artery disease (p=0.042), atrial fibrillation (AF, p=0.007) chronic kidney (CKD, baseline larger right ventricle end-diastolic diameter (RVEDD, p<0.001) worse ejection fraction (LVEF, p=0.048). univariate multivariate analyses, AF (HR 2.3, CI 1.2–4.5, p=0.011) RVEDD 2.4, 1.3–4.4, p=0.003) independent predictors progression. 57 (27%) significantly (p=0.015) group compared without progression; analyses showed 4.3, 2.1–9.1, p<0.001), CKD 3.2, 1.5–7.1, p=0.002) LVEF 0.9, 0.93–0.99, being independently associated outcome. Moreover, both CV (p=0.003) hospitalization (p=0.0139) Conclusions Our results that by progressing relevant proportion over follow-up, increases risk mortality We identified specific factors progression, which could help identify before this disease. believe should be appropriately managed closely followed-up avoid adverse events related natural valvulopathy. Funding Acknowledgement Type funding sources: None.